Calcipotriene,
a vitamin D analogue
Adds to the anti-inflammatory effect of BDP by:
Mediating psoriasis-specific immune-modulating activityIncreases keratinocyte differentiationInhibits epidermal hyperproliferationBetamethasone dipropionate,
a high-potency corticosteroid
Anti-inflammatory effects resulting in decreased expression of key cytokines:
TNF-αIL-23IL-17A/FBDP: betamethasone dipropionate; Cal: calcipotriene; IL: interleukin; TNF: tumor necrosis factor.
INDICATION: Wynzora® (calcipotriene and betamethasone dipropionate) Cream, 0.005%/0.064% is indicated for the topical treatment of plaque psoriasis in patients 18 years of age and older. ADVERSE EVENTS: In the pivotal trial, the most common adverse reactions (≥1%) were: upper respiratory infection (7%), headache (2%), and application site infection (1%). WARNINGS AND PRECAUTIONS: For topical use only. Patients should not use more than 100g of Wynzora® Cream per week. Do not use near or in the mouth, eyes or intravaginally. Avoid using Wynzora® Cream on the face, groin or armpits, or if they have atrophy at the treatment site. Discontinue use once plaque psoriasis is under control or at 8 weeks. Do not use Wynzora® Cream with occlusive dressings. Hypercalcemia and hypercalciuria have been observed with topical use of calcipotriene. Wynzora® Cream can cause reversible HPA axis suppression with the potential for clinical glucocorticosteroid insufficiency during and after withdrawal of treatment. Wynzora® Cream may cause vision problems, including increasing the risk of cataracts and glaucoma. It is not known if Wynzora® Cream may harm your unborn baby. Breastfeeding women should not apply Wynzora® Cream directly to the nipple or areola; it is not known whether topically administered calcipotriene and betamethasone dipropionate is absorbed in human milk.
Please see Full Prescribing Information for Wynzora.
You are encouraged to report side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.
References: 1. Praestegaard M, Steele F, Crutchley N. Polyaphron dispersion technology, a novel topical formulation and delivery system combining drug penetration, local tolerability and convenience of application. Dermatol Ther (Heidelb). 2022;12(10):2217-2231. doi:10.1007/s13555-022-00794-y 2. Satake K, Amano T, Okamoto T. Calcipotriol and betamethasone dipropionate synergistically enhances the balance between regulatory and proinflammatory T cells in a murine psoriasis model. Sci Rep. 2019;9(1):16322. doi:10.1038/s41598-019-52892-1 3. Lovato P, Norsgaard H, Tokura Y, Røpke MA. Calcipotriol and betamethasone dipropionate exert additive inhibitory effects on the cytokine expression of inflammatory dendritic cell-Th17 cell axis in psoriasis. J Dermatol Sci. 2016;81(3):153-164. doi:10.1016/j.jdermsci.2015.12.009 4. Segaert S, Shear NH, Chiricozzi A, et al. Optimizing anti-inflammatory and immunomodulatory effects of corticosteroid and vitamin D analogue fixed-dose combination therapy. Dermatol Ther (Heidelb). 2017;7(3):265-279. doi:10.1007/s13555-017-0196-z 5. Lowes MA, Suárez-Fariñas M, Krueger JG. Immunology of psoriasis. Annu Rev Immunol. 2014;32:227-255. doi:10.1146/annurev-immunol-032713-120225 6. Hawkes JE, Chan TC, Krueger JG. Psoriasis pathogenesis and the development of novel, targeted immune therapies. J Allergy Clin Immunol. 2017;140(3):645-653. doi:10.1016/j.jaci.2017.07.004 7. Crutchley N, Georgiou M, Praestegaard M, Steele F. PAD Technology™-based CAL/BDP cream demonstrates superior human skin flux properties compared to topical suspension/gel. Poster presented at: The Fall Clinical Dermatology Conference; October 20-23, 2023; Las Vegas, Nevada.
